Author Archives: Lex Fridman

#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years

David Sinclair is a geneticist at Harvard and author of Lifespan. Please support this podcast by checking out our sponsors:
– Onnit: https://lexfridman.com/onnit to get up to 10% off
– Clear: https://clearme.com/lexpod and use code LexPod to get 2 months free
– National Instruments (NI): https://www.ni.com/perspectives
– SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera
– Linode: https://linode.com/lex to get $100 free credit

EPISODE LINKS:
David’s Twitter: https://twitter.com/davidasinclair
David’s Website: https://lifespanbook.com

PODCAST INFO:
Podcast website: https://lexfridman.com/podcast
Apple Podcasts: https://apple.co/2lwqZIr
Spotify: https://spoti.fi/2nEwCF8
RSS: https://lexfridman.com/feed/podcast/
YouTube Full Episodes: https://youtube.com/lexfridman
YouTube Clips: https://youtube.com/lexclips

SUPPORT & CONNECT:
– Check out the sponsors above, it’s the best way to support this podcast
– Support on Patreon: https://www.patreon.com/lexfridman
– Twitter: https://twitter.com/lexfridman
– Instagram: https://www.instagram.com/lexfridman
– LinkedIn: https://www.linkedin.com/in/lexfridman
– Facebook: https://www.facebook.com/lexfridman
– Medium: https://medium.com/@lexfridman

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(09:34) – Staying young at heart
(13:31) – Bringing people back to life
(19:05) – Wearables and tracking health data
(28:18) – How to solve aging
(38:23) – Why do we age?
(43:50) – Genetic reset switch that reverses aging
(46:20) – AI in biology
(48:52) – Health data
(56:58) – Fasting
(1:04:29) – Diet
(1:12:41) – Exercise
(1:18:01) – Sleep
(1:26:29) – Data
(1:32:00) – Extending lifespan
(1:34:42) – Immortality
(1:40:28) – Denial of death
(1:43:45) – Meaning of life without death

#188 – Vitalik Buterin: Ethereum 2.0

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Vitalik Buterin is the co-founder of Ethereum. Please support this podcast by checking out our sponsors:
– Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil
– Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off
– Indeed: https://indeed.com/lex to get $75 credit
– Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off
– BetterHelp: https://betterhelp.com/lex to get 10% off

EPISODE LINKS:
Vitalik’s Twitter: https://twitter.com/VitalikButerin
Vitalik’s Blog: https://vitalik.ca/

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(08:18) – Shiba Inu story
(25:35) – Regulation
(29:48) – Crime
(34:54) – Proof of stake vs proof of work
(47:43) – Miner extractable value
(53:19) – Scaling
(54:42) – Bitcoin blocksize wars
(1:00:51) – Hard fork vs soft fork
(1:04:34) – Craig Wright
(1:11:18) – Scaling: Sharding
(1:18:07) – Scaling: Rollups
(1:26:30) – Polygon and other Layer 2 technologies
(1:34:11) – Merging PoS and PoW chains
(1:43:49) – Lessons learned from Ethereum 2.0 failure incidents
(1:52:35) – Bitcoin vs Ethereum
(1:58:30) – Dogecoin
(2:04:38) – Elon Musk
(2:07:15) – Chainlink
(2:10:35) – Charles Hoskinson and Cardano
(2:18:08) – AI safety
(2:23:07) – NFTs
(2:25:57) – Scams
(2:35:34) – Longevity
(2:44:55) – Does death give meaning to life?
(2:50:38) – Lex and Vitalik speak Russian
(2:54:29) – Meaning of life
(2:59:48) – Dan Carlin’s Hardcore History and WWII

#187 – Frank Wilczek: Physics of Quarks, Dark Matter, Complexity, Life & Aliens

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Frank Wilczek is a Nobel Prize winning physicist at MIT. Please support this podcast by checking out our sponsors:
– The Information: https://theinformation.com/lex to get 75% off first month
– NetSuite: http://netsuite.com/lex to get free product tour
– ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free
– Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium
– Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings

EPISODE LINKS:
Frank’s Twitter: https://twitter.com/FrankWilczek
Frank’s Website: https://www.frankawilczek.com/
Fundamentals: Ten Keys to Reality (book): https://amzn.to/3vLPyQB

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(08:39) – Are there limits to what physics can understand?
(17:31) – Beautiful ideas in physics
(25:59) – Space and time are really big
(29:47) – There are billions of thoughts in a human life
(37:09) – Big bang
(45:31) – How life emerged in the universe
(51:33) – Aliens
(1:01:25) – Consciousness
(1:08:53) – Limits of physics
(1:14:29) – Complimentary principle
(1:23:34) – Free will
(1:29:47) – Particles
(1:35:10) – Nobel Prize in Physics
(1:48:24) – Axions and dark matter
(2:03:50) – Time crystals
(2:08:42) – Theory of everything
(2:18:10) – Advice for young people
(2:23:52) – Meaning of life

#186 – Bryan Johnson: Kernel Brain-Computer Interfaces

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Bryan Johnson is the founder and CEO of Kernel, OS Fund, and previously Braintree. Please support this podcast by checking out our sponsors:
– Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off
– NetSuite: http://netsuite.com/lex to get free product tour
– Grammarly: https://grammarly.com/lex to get 20% off premium
– ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free

EPISODE LINKS:
Bryan’s Twitter: https://twitter.com/bryan_johnson
Bryan’s Website: https://www.bryanjohnson.co/
Kernel’s Twitter: https://twitter.com/KernelCo
Kernel’s Website: https://www.kernel.com/

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(06:57) – Kernel Flow demo
(16:10) – The future of brain-computer interfaces
(49:39) – Existential risk
(55:18) – Overcoming depression
(1:10:36) – Zeroth principles thinking
(1:18:50) – Engineering consciousness
(1:25:03) – Privacy
(1:29:33) – Neuralink
(1:39:11) – Braintree and Venmo
(1:54:54) – Eating one meal a day
(2:01:07) – Sleep
(2:20:49) – Climbing Mount Kilimanjaro
(2:27:47) – Advice for young people
(2:32:23) – Meaning of life

#185 – Sam Harris: Consciousness, Free Will, Psychedelics, AI, UFOs, and Meaning

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Sam Harris is an author, podcaster, and philosopher. Please support this podcast by checking out our sponsors:
– National Instruments (NI): https://www.ni.com/perspectives
– Belcampo: https://belcampo.com/lex and use code LEX to get 20% off first order
– Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil
– Linode: https://linode.com/lex to get $100 free credit

EPISODE LINKS:
Sam’s Twitter: https://twitter.com/SamHarrisOrg
Sam’s Website: https://samharris.org/
Sam’s YouTube: https://www.youtube.com/channel/UCNAxrHudMfdzNi6NxruKPLw

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(08:18) – Where do thoughts come from?
(14:18) – Consciousness
(31:50) – Psychedelics
(41:14) – Nature of reality
(58:09) – Free will
(1:56:55) – Ego
(2:05:59) – Joe Rogan
(2:08:59) – How will human civilization destroy itself?
(2:16:27) – AI
(2:37:10) – Jordan Peterson
(2:45:12) – UFOs
(2:53:02) – Brazilian Jiu Jitsu
(3:02:47) – Love
(3:13:50) – Meaning of life

#184 – Katherine de Kleer: Planets, Moons, and Asteroids in Our Solar System

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Katherine de Kleer is a professor of Planetary Science and Astronomy at Caltech. Please support this podcast by checking out our sponsors:
– Fundrise: https://fundrise.com/lex
– Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium
– ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free
– Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off

EPISODE LINKS:
Katherine’s Website: http://web.gps.caltech.edu/~dekleer/

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(07:07) – Pluto
(12:14) – Kuiper belt
(16:12) – How to study planets and moons
(19:54) – Volcanoes on Io – moon of Jupiter
(32:25) – Is there life in the oceans of Europa?
(41:46) – How unlikely is life on Earth?
(52:15) – Life on Venus
(54:30) – Mars
(1:01:17) – What is interesting about Earth as a planet?
(1:11:55) – Weather patterns
(1:17:04) – Asteroids
(1:26:06) – Will an asteroid hit Earth soon?
(1:34:50) – Oumuamua
(1:50:00) – Book recommendations
(1:56:37) – Advice for young people

#183 – Po-Shen Loh: Mathematics, Math Olympiad, Combinatorics & Contact Tracing

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Po-Shen Loh is a mathematician at CMU and coach of the USA International Math Olympiad team. Please support this podcast by checking out our sponsors:
– The Jordan Harbinger Show: https://jordanharbinger.com/lex/
– Onnit: https://lexfridman.com/onnit
– BetterHelp: https://betterhelp.com/lex to get 10% off
– Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings
– LMNT: https://drinkLMNT.com/lex to get free sample pack

EPISODE LINKS:
Po’s Twitter: https://twitter.com/poshenloh
Po’s Website: https://www.poshenloh.com/
Daily Challenges: https://daily.poshenloh.com/
NOVID: https://www.novid.org/

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(08:51) – Planes and bridges
(12:28) – Writing a computer game from scratch
(14:54) – Programming competitions
(18:28) – Math is hard
(23:59) – Contact tracing that preserves privacy
(1:01:16) – Math Olympiad
(1:16:57) – Hard math problem
(1:24:14) – Is math discovered or invented?
(1:29:09) – Intelligence
(1:35:59) – Math education
(1:40:10) – How to learn math
(1:49:06) – Combinatorics
(1:52:13) – Voting trees
(2:02:36) – Stochastic coalescence
(2:12:23) – P=NP
(2:16:39) – Tolkien and WWII
(2:19:00) – Advice for young people
(2:21:05) – Meaning of life

#182 – John Danaher: The Path to Mastery in Jiu Jitsu, Grappling, Judo, and MMA

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John Danaher is a coach, scholar, and educator of jiu jitsu, submission grappling, judo, MMA, and the martial arts. Please support this podcast by checking out our sponsors:
– Onnit: https://lexfridman.com/onnit
– SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera
– Indeed: https://indeed.com/lex to get $75 credit
– Linode: https://linode.com/lex to get $100 free credit

EPISODE LINKS:
John’s Instagram: https://www.instagram.com/danaherjohn

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(07:02) – Fear of death
(17:18) – The path to greatness
(22:57) – Judo
(27:07) – Seoi nage judo throw
(39:21) – Fundamentals of jiu jitsu
(45:34) – Developing new techniques
(53:24) – Value of training with lower belts
(1:03:23) – Escaping bad positions
(1:10:18) – Submissions
(1:14:30) – Reinventing yourself in 5 years
(1:30:38) – Drilling
(1:49:10) – Leglock system
(2:08:44) – How hard is it to break a leg?
(2:12:52) – Greatest jiu jitsu player ever
(2:17:42) – Roger Gracie
(2:22:25) – Gordon Ryan
(2:27:16) – Georges St-Pierre
(2:36:26) – Superintelligent Robot vs Cyborg Gordon Ryan
(3:12:07) – Advice to white belts
(3:15:24) – What does it take to get a black belt
(3:16:09) – Best martial art for street fighting
(3:23:23) – Tie chokes
(3:27:44) – Austin
(3:32:23) – Meaning of life

#181 – Sergey Nazarov: Chainlink, Smart Contracts, and Oracle Networks

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Sergey Nazarov is the Co-Founder of Chainlink, a decentralized oracle network that provides data to smart contracts. Please support this podcast by checking out our sponsors:
– Wine Access: https://wineaccess.com/lex to get 20% off first order
– Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil
– Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off
– Indeed: https://indeed.com/lex to get $75 credit
– BetterHelp: https://betterhelp.com/lex to get 10% off

EPISODE LINKS:
Sergey’s Twitter: https://twitter.com/SergeyNazarov
Chainlink Website: https://chain.link/

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(07:56) – Hedgy
(08:22) – Digital vs physical world
(16:16) – Definitive truth
(20:31) – Decentralized finance
(29:00) – Smart contracts
(35:16) – Hybrid smart contracts and oracle networks
(52:02) – Applications of smart contracts
(1:10:08) – AI and smart contracts
(1:17:40) – What agreements can be turned into smart contracts?
(1:28:43) – Privacy
(1:39:01) – Trust
(1:54:36) – Bitcoin
(2:02:50) – Satoshi Nakamoto
(2:10:10) – Ethereum
(2:15:59) – Chainlink design decisions
(2:28:27) – Dogecoin
(2:32:44) – Book recommendations
(2:44:54) – Advice for young people
(2:56:58) – Meaning of life

#180 – Jeremi Suri: History of American Power

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Jeremi Suri is a historian at UT Austin. Please support this podcast by checking out our sponsors:
– LMNT: https://drinkLMNT.com/lex to get free sample pack
– Munk Pack: https://munkpack.com and use code LEX to get 20% off
– Belcampo: https://belcampo.com/lex and use code LEX to get 20% off first order
– Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off
– Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings

EPISODE LINKS:
Jeremi’s Twitter: https://twitter.com/JeremiSuri
Jeremi’s Website: http://jeremisuri.net
This is Democracy Podcast: http://jeremisuri.net/archives/1798
The Impossible Presidency (book): https://amzn.to/2QKC5Jp

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(14:33) – Power of charisma
(20:24) – US presidency
(31:10) – Aliens
(36:17) – Bill Clinton
(39:07) – Students of history
(43:58) – George Washington
(46:44) – Putin
(53:27) – FDR
(1:08:39) – Henry Kissinger
(1:18:32) – Realpolitik
(1:30:22) – What is a just war?
(1:36:27) – Cold war
(1:40:44) – Communism in the United States
(1:50:42) – Vaccines and the future of the human species
(1:55:57) – Book recommendations
(1:57:31) – Learning another language
(2:01:58) – Advice for young people
(2:08:10) – Grandmother
(2:11:03) – Meaning of life